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Hyperthyroidism in two patients with Crohn disease and Takayasu arteritis

A Kettaneh1, S Prevot, A Biaggi

  • 1Dept. of Internal Medicine, Hôpital Jean Verdier, Bondy, France. adrien.kettaneh@jvr.ap-hop-paris.fr

Scandinavian Journal of Gastroenterology
|August 28, 2003
PubMed

Insights

This study reports two cases of hyperthyroidism in patients with Crohn disease and Takayasu arteritis. The findings suggest a potential link between these conditions, possibly due to genetic factors and iodine deficiency impacting the Nuclear Factor kappaB pathway.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Rheumatology

Background:

  • Crohn disease (CD), Takayasu arteritis (TA), and thyroid abnormalities are independently observed in patients.
  • This report details two cases of concurrent hyperthyroidism, CD, and TA.

Observation:

  • Two women presented with hyperthyroidism alongside pre-existing CD and TA.
  • Diagnostic evaluations included thyroid function tests, antibody assays, ultrasonography, and iodine uptake scans.
  • Both patients underwent subtotal thyroidectomy due to persistent thyrotoxicosis.

Findings:

  • Neither patient had detectable anti-thyrotropin receptor (TRAK) or anti-thyroid antibodies.
  • Thyroid imaging revealed multinodular goiter and hot nodules in both cases.
  • The co-occurrence of these three conditions suggests a potential non-fortuitous association.

Implications:

  • The shared association may stem from genetic predispositions and disease-related iodine deficiency.
  • The Nuclear Factor kappaB pathway is hypothesized to play a role in the pathogenesis of this triad of diseases.
  • Further research is warranted to elucidate the underlying mechanisms connecting CD, TA, and thyroid dysfunction.

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