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Related Experiment Video

Updated: Jul 21, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Hepatic 'stem cell' malignancies in adults: four cases.

N D Theise¹, J L Yao, K Harada

¹Department of Pathology, New York University Medical Center, New York, NY, USA. ntheise@chpnet.org

|August 28, 2003

Summary

This study suggests human hepatic progenitor cells may transform into malignant tumors. These findings support the origin of some mixed hepatocellular/cholangiocarcinomas from these progenitor cells.

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Area of Science:

Hepatology
Gastroenterology
Oncology

Background:

Combined hepatocellular/cholangiocarcinomas are hypothesized to arise from bidirectional differentiation of neoplastic progenitor cells.
Human hepatic progenitor cells have been identified, but their role in malignant transformation remains unconfirmed.

Purpose of the Study:

To investigate the potential role of hepatic progenitor cells in the development of hepatic malignancies.
To examine four cases of small liver tumors in patients with chronic hepatitis.

Main Methods:

Histochemistry and immunohistochemistry were used to study tumor samples from four patients.
Analysis focused on identifying undifferentiated cells with progenitor cell characteristics.

Main Results:

All tumors contained undifferentiated cells resembling hepatic progenitor cells.
These progenitor-like cells were observed to merge with both hepatocellular carcinoma and cholangiocarcinoma components.
Patients had varying stages of chronic liver disease, including hepatitis B, C, and alcoholic injury.

Conclusions:

The study suggests these tumors originate from hepatic progenitor cells.
This supports the concept that human hepatocarcinogenesis can involve progenitor cell transformation.
This mechanism may explain the development of some mixed hepatocellular/cholangiocarcinomas and dysplastic nodules.