Higher renal replacement therapy dose delivery influences on drug therapy
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Updated: Sep 20, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Bruce A Mueller1, Deborah A Pasko, Kevin M Sowinski
1Clinical Sciences Department, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. muellerb@umich.edu
Abstract:
Higher doses of renal replacement therapy have profound effects on pharmacotherapy, yet little research has been conducted in this area. High-volume renal replacement therapies influence both the pharmacokinetic and the pharmacodynamic profiles of all drugs administered to these critically ill patients. Intermittent high-dose "hybrid" hemodialysis therapies remove drugs to a much different degree than standard thrice-weekly hemodialysis, yet pharmacokinetic studies have not been performed in patients receiving these therapies. High-volume continuous renal replacement therapies offer dosing challenges not seen with standard low-dose therapies. This article describes the pharmacokinetic and pharmacodynamic issues presented by high-volume renal replacement therapies. Given the importance that pharmacotherapy has on optimal patient outcomes, a better understanding of the influence that high-volume renal replacement therapy has on drugs is essential if these high volume therapies are to be used successfully in the intensive care unit.
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