Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gap junctional hemichannels in the heart.

S John1, D Cesario, J N Weiss

  • 1UCLA Cardiovascular Research Laboratory, Department of Medicine (Cardiology) and Physiology, The David Geffen School of Medicine at UCLA, 90095-1760, USA.

Acta Physiologica Scandinavica
|August 28, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Active TB case finding in returnee coalminers and their home district communities in Pakistan.

Public health action·2025
Same author

A Randomized Hybrid Type I Effectiveness-Implementation Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer (eREACH2): study protocol.

medRxiv : the preprint server for health sciences·2025
Same author

Improving TB care services among coal mine workers and their associated communities in Pakistan.

Public health action·2025
Same author

Outcome of active TB case finding among a nomadic population in Nigeria.

Public health action·2025
Same author

TNF-α polymorphism in oral cancer and oral potentially malignant disorders: meta-analysis and investigation as a potential tool to determine individual susceptibility and the prognosis.

International journal of oral and maxillofacial surgery·2025
Same author

Recommencing anticoagulation treatment in surgically managed patients with intracerebral haemorrhage and mechanical heart valves: An Aotearoa-New Zealand analysis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
Same journal

Airborne nitric oxide: Inflammatory marker and aerocrine messenger in man.

Acta physiologica Scandinavica·2017
Same journal

Respiratory and Circulatory Responses to Different Types of Exercise.

Acta physiologica Scandinavica·2017
Same journal

Relative and Total Hemoglobin Content of the Blood and Maximal Oxygen Uptake.

Acta physiologica Scandinavica·2017
Same journal

Summary.

Acta physiologica Scandinavica·2017
Same journal

General Introduction.

Acta physiologica Scandinavica·2017
Same journal

Maximal Oxygen Uptake in Norwegian Subjects.

Acta physiologica Scandinavica·2017
See all related articles

Heart ventricular myocytes have hemichannels (connexons) that regulate cell communication. These channels open under stress via dephosphorylation, potentially impacting heart function and disease.

Area of Science:

  • Cell Biology
  • Cardiovascular Physiology

Background:

  • Cells communicate via gap junctions, formed by hemichannels (connexons).
  • Hemichannels facilitate molecular exchange between adjacent cell cytoplasms.

Purpose of the Study:

  • To review evidence for hemichannel function in heart ventricular myocytes.
  • To explore hemichannel regulation and its physiological implications.

Main Methods:

  • Morphological analysis of hemichannel insertion into plasma membranes.
  • Electrophysiological detection and dye uptake assays for functional assessment.
  • In vivo studies on biological regulation of hemichannels.

Main Results:

  • Hemichannels are inserted into the plasma membrane and can be detected functionally.

Related Experiment Videos

  • Phosphorylation, regulated by MAPK pathways, keeps hemichannels closed under normal conditions.
  • Stress (hyperosmolarity, metabolic inhibition) dephosphorylates hemichannels, leading to opening and ion flux.

    • Conclusions:

    • Hemichannel opening in heart cells is regulated by phosphorylation/dephosphorylation.
    • Open hemichannels allow dye uptake and ion exchange, potentially affecting heart physiology and pathophysiology.