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In the beginning: lessons from fertilization in mice and worms

Melissa K Jungnickel1, Keith A Sutton, Harvey M Florman

  • 1Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Cell
|August 28, 2003
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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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