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Synthesis and anti-inflammatory activity of 2-pyridyl-2-thiobenzothiazole derivatives
J F Lagorce1, M Lakhdar, J Fatimi
1Department of Therapeutic and Organic Chemistry, Faculty of Pharmacy, University of Limoges, France.
Farmaco (Societa Chimica Italiana : 1989)
|December 1, 1992
Abstract:
A series of novel 2-pyridyl-2-thiobenzothiazole compounds was prepared and investigated by a number of in vitro methods in order to determine their anti-inflammatory properties. Results are discussed with reference to well known NSAIDs. (3-carboxy-2-pyridyl)-2-thiobenzothiazole had the most potent anti-inflammatory activity, being 1.34 times more active than indomethacin used as reference compound.