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Cardiac output: a view from Buffalo.

A J Olszowka1, B E Shykoff, D R Pendergast

  • 1The Herman Rahn Laboratory, Department of Physiology and Biophysics and the Center for Research and Education in Special Environment, University at Buffalo, Buffalo, New York, USA.

European Journal of Applied Physiology
|August 28, 2003
PubMed
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The Buffalo CO2 rebreathing method accurately measures cardiac output (Q) indirectly. This technique is reliable for assessing cardiovascular function during various environmental stresses and exercise.

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Environmental Medicine

Background:

  • Cardiac output (Q) is vital for homeostasis, blood pressure, and oxygen delivery, especially under environmental stress.
  • Invasive methods for Q measurement are limited to clinical settings, necessitating reliable indirect techniques.
  • Traditional indirect methods for Q assessment have limitations, particularly during physiological stress.

Purpose of the Study:

  • To present a validated and reliable indirect method for measuring cardiac output (Q).
  • To highlight the utility of the Buffalo CO2 rebreathing method in diverse physiological and environmental conditions.

Main Methods:

  • The study utilizes a revised single-step CO2 rebreathing technique developed by Farhi and colleagues.
  • Measurements include carbon dioxide output (VCO2), partial pressure of arterial CO2 (PaCO2), and partial pressure of mixed venous CO2 (Pv(CO2)) during 12-25 seconds of rebreathing.

Related Experiment Videos

  • Cardiac output (Q) is calculated using determined CO2 variables and appropriate tidal volume.

    • Main Results:

    • The Buffalo CO2 rebreathing method has demonstrated validity and reliability compared to direct Q measurements.
    • This method provides accurate data across various conditions, including exercise, microgravity, water immersion, and altered gas environments.
    • The study shows that cardiac output (Q) effectively adjusts to environmental changes, maintaining blood pressure and oxygen delivery.

    Conclusions:

    • The Buffalo CO2 rebreathing method is a robust tool for indirect cardiac output (Q) assessment.
    • This technique is suitable for laboratory and field studies, offering accurate physiological data during stress.
    • The findings underscore the adaptability of cardiac output (Q) to environmental challenges.