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Recurring thrombocytopenia associated with structured treatment interruption in patients with human immunodeficiency
Jintanat Ananworanich1, Nittaya Phanuphak, Reto Nuesch
1Human Immunodeficiency Virus Netherlands Australia Thailand Research Collaboration and Thai Red Cross Acquired Immunodeficiency Syndrome Research Center, Pathumwan, Bangkok, Thailand 10330. jintanat.a@chula.ac.th
Abstract:
In a structured treatment interruption (STI) trial, 3 of 23 patients in a CD4 cell count-guided treatment arm developed recurring thrombocytopenia associated with the interruption of antiretroviral therapy. All 3 patients had slightly low or normal platelet counts before initiating antiretroviral therapy. STI may play a role in inducing thrombocytopenia in patients with human immunodeficiency virus infection.