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Updated: Sep 20, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
Antisaccade performance of 1,273 men: effects of schizotypy, anxiety, and depression
Nikolaos Smyrnis1, Ioannis Evdokimidis, Nicholas C Stefanis
1University Mental Health Research Institute, Neurology Department, National University of Athens, Greece. smyrnis@med.uoa.gr
Abstract:
A total of 1,273 conscripts of the Greek Air Force performed antisaccades and completed self-reporting questionnaires measuring schizotypy and current state-dependent psychopathology. Only 1.0% of variability in antisaccade performance indices was related to psychometric scores in the population and could be attributed more to current state-dependent symptoms such as anxiety rather than to schizotypy. In contrast, a specific increase of error rate and response latency variability and a high correlation of these 2 variables was observed in a group with very high schizotypy scores. This effect was independent of anxiety and depression, suggesting that a specific group of psychosis-prone individuals has a characteristic deviance in antisaccade performance that is not present in the general population.
