Cognitive predictors of symptom return following depression treatment
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Updated: Sep 20, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Christopher G Beevers1, Gabor I Keitner, Christine E Ryan
1Department of Psychiatry and Human Behavior, Brown University and Psychosocial Research Program, Butler Hospital, Providence, Rhode Island 02906, USA. christopher_beevers@brown.edu
Abstract:
This study tested whether poor cognitive change during depression treatment predicted time to return of depressive symptoms. Depressed participants (N = 121) completed assessments of dysfunctional attitudes and extreme thinking (i.e., number of totally agree and totally disagree responses) during hospitalization and again after 6 months of outpatient treatment. Participants then completed monthly depression assessments for 1 year. Survival analyses for time to symptom recurrence during follow-up were conducted among participants who reported 50% improvement in their depressive symptoms and were at least partially asymptomatic at the end of treatment (n = 53). Poor change in dysfunctional attitudes and poor change in extreme thinking both predicted shorter time to return of depressive symptoms.
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