Related Experiment Video
Updated: Apr 1, 2026
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
Overweight, dyslipoproteinemia, and heart rate variability measures
Nadezhda I Doncheva1, Rouja I Nikolova, Svetoslav G Danev
1Lipid Laboratory, Medical Institute-Ministry of Interior, Sofia, Bulgaria. ckb-npi@mbox.infotel.bg
Insights
Chronic stress negatively impacts heart rate variability, increasing risks for overweight, dyslipoproteinemia, and coronary artery disease. This study links physical stress to higher serum lipids and body mass index.
Area of Science:
- Cardiology
- Endocrinology
- Psychophysiology
Background:
- Chronic stress is a potential risk factor for overweight, dyslipoproteinemia, and coronary artery disease.
- Understanding the physiological markers of stress is crucial for managing these conditions.
Purpose of the Study:
- To investigate the association between stress, measured by heart rate variability, and dyslipoproteinemia and overweight.
- To explore the relationship between stress markers and cardiovascular risk factors.
Main Methods:
- Analyzed serum lipids (total cholesterol, HDL, LDL, triglycerides) using enzyme methods.
- Evaluated heart rate variability (HRV) in 47 individuals with dyslipoproteinemia using computer analysis of cardiointervals.
Main Results:
- Found positive correlations between stress indicators and lipid levels, and body mass index.
- Observed negative correlations between total and LDL cholesterol and HRV measures.
- Identified chronically increased health risk in a significant portion of participants, many with elevated BMI.
Conclusions:
- Heart rate variability measures are reduced in individuals with dyslipoproteinemia.
- Chronic stress, particularly physical stress, is associated with adverse lipid profiles, overweight, and increased coronary artery disease risk.
- Autonomic nervous system imbalances, specifically sympathetic overactivity, may mediate the effects of chronic stress on cardiovascular health.
Unlabelled:
Chronic stress could be a risk factor triggering, aggravating or causing overweight, dyslipoproteinemia and coronary artery disease.
Objective:
The purpose of this study was to determine the association between stress assessed by heart rate variability measures, dyslipoproteinemia, and overweight.
Methods:
Total cholesterol, high and low density lipoproteins cholesterol and triglycerides were analyzed by enzyme methods; heart rate variability was evaluated using a computer program for analysis of cardiointervals in 47 individuals with dyslipoproteinemia.
Results:
Positive correlations were found between heart rate and low density lipoprotein cholesterol, between mental stress and total cholesterol/high density lipoprotein cholesterol, between physical stress and total cholesterol, low density lipoproteins cholesterol, triglycerides and body mass index, and between functional age and health risk, and total cholesterol and low density lipoprotein cholesterol. The total cholesterol and low density lipoprotein cholesterol were negatively correlated with the time- and frequency-domain heart rate variability measures. A chronically increased health risk (> 65%) was observed in 15 individuals with dyslipoproteinemia, 11 of them with body mass index exceeding 25.0 kg/m2.
Conclusion:
Heart rate variability measures decrease in individuals with dyslipoproteinemia. Decreasing of heart rate variability is induced by the increased activity of the sympathetic branch of the autonomic nervous system under chronic stress effect. Results of our study revealed a significant association between physical stress, serum lipids and overweight and risk of coronary artery disease.
More Related Videos
08:12Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
Published on: June 5, 2019
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Related Concept Videos
01:26Atherosclerosis III: Management
01:31Regulation of Heart Rates
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
01:30Factors Influencing Heart Rate
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:29Cholesterol: Significance and Regulation
Considering cholesterol and...
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents