Tandem hydroformylation/Fischer indole synthesis: a novel and convenient approach to indoles from olefins
Petra Köhling1, Axel M Schmidt, Peter Eilbracht
1Fachbereich Chemie, Organische Chemie I, Universität Dortmund, Otto-Hahn-Str. 6, 44227 Dortmund.
Abstract:
[reaction: see text] A novel one-pot synthesis of indole systems via tandem hydroformylation/Fischer indole synthesis starting from olefins and arylhydrazines is described. This tandem procedure leads directly to 3-substituted indoles if unsubstituted phenylhydrazine is used and to 3,5- respectively 3,7-disubstituted indoles if para- or ortho-substituted arylhydrazines are used.
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