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Formal synthesis of (-)-apicularen A
Benjamin R Graetz1, Scott D Rychnovsky
1Department of Chemistry, 516 Rowland Hall, University of California-Irvine, Irvine, California 92697-2025, USA.
Organic Letters
|August 29, 2003
Abstract:
[reaction: see text] A formal synthesis of (-)-apicularen A has been completed. The synthesis features a cyanohydrin acetonide coupling as a convergent approach to the C9-C18 segment and an intramolecular Diels-Alder addition sequence to create both the 10-membered macrocycle and the aromatic ring.