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Pharmacogenomic profiling in postmarketing surveillance: prospects and challenges
1UCLA School of Public Health, Room 31-245A CHS, Campus Box 951772, Los Angeles, CA 90095-1772, USA. aissa1@ucla.edu
Abstract:
Adverse drug reactions (ADRs) represent a major public health and economic global problem. Growing evidence suggests that pharmacogenomics may potentially play a role in reducing drug-induced adverse events. Research efforts are increasingly directed towards this goal. However, knowledge about whether or not pharmacogenomics may be useful as a novel approach in postmarketing surveillance programs is at present rather limited. A critical analysis of some of the methodological design and ethical issues generated by the potential incorporation of pharmacogenomic profiling into pharmacosurveillance programs is presented.
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