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Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira
Irama Ramírez1, Alfredo Carabot, Pablo Meléndez
1Faculty of Pharmacy, University of Los Andes, Mérida ZP-5101, Venezuela.
Phytochemistry
|August 29, 2003
Abstract:
From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.