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Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum
Roberto C C Martins1, João Henrique G Lago, Sergio Albuquerque
1Instituto de Química, Universidade de São Paulo, C.P. 26077, 05513-970 São Paulo, Brazil.
Phytochemistry
|August 29, 2003
Abstract:
In addition to sitosterol, syringaldehyde, 3,4,5-trimethoxybenzoic acid, isoelemicin and grandisin, two new tetrahydrofuran lignans were isolated from Piper solmsianun and characterized as rel-(7R,8R,7'R,8'R)-3',4'-methylenedioxy-3,4,5,5'-tetramethoxy-7,7'-epoxylignan and rel-(7R,8R,7'R,8'R)-3,4,3',4'-dimethylenedioxy-5,5'-dimethoxy-7,7'-epoxylignan on the basis of spectroscopic data, including 2D NMR spectrometric techniques. Their in vitro activity were determined against the trypomastigote form of Trypanossoma cruzi.
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