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Protein kinase A activity in platelets from patients with bipolar disorder
Daniela Tardito1, Silvia Mori, Giorgio Racagni
1Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy. daniela_tardito@hotmail.com
Background:
Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD.
Methods:
PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls.
Results:
The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls.
Limitations:
This study made use of platelets, which may not fully represent changes occurring in specific brain regions.
Conclusion:
This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.