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Nitrous oxide as a marker for irrigating fluid absorption--an experimental study in the pig
1Karolinska Institute, Stockhom, Sweden. Robert.Holm@sos.sll.se
Scandinavian Journal of Urology and Nephrology
|August 29, 2003
Summary
Nitrous oxide (N2O) in irrigating fluid can detect fluid absorption during endoscopic procedures. This gas marker offers better resolution, lower toxicity, and faster elimination than ethanol.
Area of Science:
- Anesthesiology
- Gastroenterology
- Surgical Innovation
Background:
- Fluid absorption during endoscopic procedures is a clinical concern.
- Ethanol has been used as a marker, but has limitations.
- A need exists for a more effective marker for irrigating fluid absorption.
Purpose of the Study:
- To evaluate nitrous oxide (N2O) as a potential marker for irrigating fluid absorption.
- To compare N2O with ethanol as a breath marker.
Main Methods:
- Nitrous oxide (N2O) was dissolved in a standard irrigating fluid.
- Fluid was administered intravenously (i.v.) and intraperitoneally (i.p.) in pigs.
- N2O and ethanol concentrations were measured in expired breath.
Main Results:
- N2O readily detected i.v. fluid injections and showed rapid concentration changes.
- Breath N2O levels reached a quasi-steady state within 2 minutes of continuous infusion.
- N2O provided better resolution and faster elimination compared to ethanol, especially with i.v. administration.
Conclusions:
- Nitrous oxide (N2O) is a viable marker for detecting irrigating fluid absorption.
- N2O offers advantages over ethanol, including improved resolution, reduced toxicity, and rapid elimination.
- This method allows for real-time monitoring of fluid absorption during endoscopic procedures.