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Serum biochemical markers in carcinoma breast
Late R K Seth1, Simmi Kharb, D P Kharb
1Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana.
Indian Journal of Medical Sciences
|August 29, 2003
Summary
Serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH), and superoxide dismutase (SOD) show significantly elevated levels in breast cancer patients. These markers demonstrate increased activity from early to advanced stages, indicating their potential for early breast cancer detection.
Area of Science:
- Biochemistry
- Oncology
- Biomarkers
Background:
- The exact causes of cancer remain largely unknown despite extensive global research.
- Early detection of various cancers relies on identifying reliable biochemical markers for malignancy.
Purpose of the Study:
- To analyze serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH), and superoxide dismutase (SOD) levels in breast carcinoma patients.
- To evaluate the potential of these markers in the early detection of breast cancer.
Main Methods:
- Serum GGTP, LDH, and SOD were measured in 25 histopathologically confirmed breast cancer patients and 25 age-matched healthy controls.
- Statistical analysis using Student's t-test was performed to compare marker levels between groups.
- The sensitivity of each marker for breast cancer detection was determined.
Main Results:
- Mean serum GGTP, LDH, and SOD activities were significantly higher in breast cancer patients compared to controls.
- A progressive increase in the activities of these markers was observed from Stage I to Stage IV.
- Elevated marker levels correlated with the presence of distant metastasis.
Conclusions:
- Serum GGTP, LDH, and SOD show markedly increased activities in breast carcinoma.
- These biomarkers may serve as sensitive indicators for the early detection of breast cancer.
- The observed trend suggests their utility in monitoring disease progression.