Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnostics and therapy of neuropathic pain].

Der Anaesthesist·2021
Same author

Increased risk of acute stroke among patients with severe COVID-19: a multicenter study and meta-analysis.

European journal of neurology·2020
Same author

[Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest) for assessment of non-motor symptoms in dystonia : Intercultural adaptation in the German language].

Der Nervenarzt·2020
Same author

MMW Fortschritte der Medizin·2019
Same author

Surgical decision-making in infants with suspected UPJ obstruction: stakeholder perspectives.

Journal of pediatric urology·2019
Same author

Mutation in Na<sub>v</sub> 1.7 causes high olfactory sensitivity.

European journal of pain (London, England)·2018

Related Experiment Video

Updated: Jul 10, 2026

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

HLA typing and Parkinson's disease.

J B Lampe1, G Gossrau, B Herting

  • 1Department of Neurology, University of Technology, Dresden, Germany. johannes.lampe@schering.de

European Neurology
|August 29, 2003
PubMed
Summary

Researchers investigated the genetic links to idiopathic Parkinson's disease (IPD). A specific HLA allele, DQB1*06, was found more frequently in German IPD patients, suggesting a potential immune system connection.

More Related Videos

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human &#945;-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
09:21

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Related Experiment Videos

Last Updated: Jul 10, 2026

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human &#945;-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
09:21

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Area of Science:

  • Neuroimmunology
  • Human Genetics
  • Neurology

Background:

  • Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder with an unknown cause.
  • Previous studies have suggested associations between IPD and specific antigens using serological methods.
  • The role of human leukocyte antigen (HLA) genes in IPD pathogenesis remains an area of active research.

Purpose of the Study:

  • To systematically analyze HLA class I and II alleles in a cohort of German Caucasian IPD patients.
  • To identify specific HLA alleles associated with an increased risk or prevalence of IPD.
  • To explore the potential involvement of the immune system in the etiology of IPD.

Main Methods:

  • Analysis of HLA class I and II alleles in 45 German Caucasian IPD patients.
  • Utilized sequence-specific oligonucleotide (SSO) and sequence-specific primer (SSP) technologies for allele typing.
  • Statistical analysis with Bonferroni correction to determine significance (p < 0.05).

Main Results:

  • A statistically significant increase in the frequency of the DQB1*06 allele was observed in IPD patients compared to controls (p = 0.002).
  • This finding suggests a potential association between the DQB1*06 allele and the development of IPD.
  • The observed association may imply a role for immune system dysregulation in IPD.

Conclusions:

  • The increased prevalence of the HLA-DQB1*06 allele in German Caucasian IPD patients suggests a genetic predisposition.
  • This finding supports the hypothesis that immune system mechanisms may contribute to the pathogenesis of idiopathic Parkinson's disease.
  • Further research is warranted to elucidate the functional relevance of HLA alleles and their potential linkage disequilibrium with other susceptibility genes in IPD.