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Renal parameters during infancy.

K P Mehta1, S R Karnik, A Sathe

  • 1Department of Pediatrics, Jaslok Hospital and Research Centre, Bombay.

Indian Pediatrics
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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Neonatal renal function shows immature acidification, leading to mild metabolic acidosis and hyperchloremia. High renin and aldosterone levels are also normal in infants up to six months old.

Area of Science:

  • Pediatric Nephrology
  • Neonatal Physiology

Background:

  • Renal function in neonates differs significantly from adults.
  • Understanding these early changes is crucial for accurate assessment.

Purpose of the Study:

  • To prospectively evaluate key renal parameters in healthy term neonates.
  • To track these parameters through the first year of life.

Main Methods:

  • Prospective study of 48 full-term neonates.
  • Repeated measurements at 6 and 12 months for 15 infants.
  • Assessed serum creatinine, uric acid, blood gases, electrolytes, plasma renin activity, and aldosterone.
  • Renal size evaluated by ultrasonography.

Main Results:

  • Elevated serum creatinine and uric acid at birth, normalizing by 6 months.

Related Experiment Videos

  • Low blood pH and bicarbonate at birth, reaching adult levels by 12 months.
  • High chloride levels at birth, normalizing by 6 months.
  • Persistently high plasma renin activity and elevated plasma aldosterone at birth, decreasing by 12 months.
  • Renal length and volume within normal American standards.

    • Conclusions:

    • Mild metabolic acidosis and hyperchloremia in neonates are due to immature renal acidification.
    • High renin and aldosterone levels indicate partial distal tubule nonresponsiveness, a normal finding.
    • Elevated neonatal serum creatinine and uric acid are expected and should be considered when assessing renal function.