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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
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[Target organ effects in untreated hypertension]

D Babici1, I M'Pio, A Hadj-Aïssa

  • 1Département de néphrologie et d'hypertension artérielle, hôpital Edouard Herriot, Université C. Bernard Lyon 1, EA 645, 69437 Lyon.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|August 30, 2003
PubMed

Insights

Untreated hypertension can cause early kidney and heart damage, especially in permanent hypertensives. Ambulatory blood pressure monitoring is crucial for identifying these risks, as white coat hypertensives show no significant organ effects.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Context:

  • Systemic hypertension often leads to renal and cardiac complications, yet parallel investigations in untreated individuals are rare.
  • Differentiating between white coat hypertension and sustained hypertension is critical for understanding target organ effects.

Purpose:

  • To assess renal function (glomerular filtration rate, renal plasmatic debit, microalbuminuria) and cardiac function (left ventricular mass index) in never-treated hypertensive patients.
  • To compare renal and cardiac parameters between white coat hypertensives, permanent hypertensives, and normotensive subjects based on 24-hour blood pressure.

Summary:

  • Permanent hypertensives exhibited reduced renal plasmatic debit, increased microalbuminuria, and higher left ventricular mass index compared to normotensives and white coat hypertensives.
  • White coat hypertensives showed normal renal function, while permanent hypertensives had significantly impaired glomerular filtration rate and renal plasmatic debit.
  • Ambulatory systolic blood pressure correlated with microalbuminuria and left ventricular mass index in all hypertensive subjects, indicating a continuum of organ effects.

Impact:

  • Ambulatory blood pressure monitoring is essential for detecting early renal and cardiac damage in permanent hypertensives.
  • This study highlights that white coat hypertension does not appear to cause significant early target organ damage.
  • Findings underscore the importance of continuous blood pressure monitoring for personalized hypertension management and risk stratification.

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