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Synthesis and structural study of two new heparin-like hexasaccharides
Ricardo Lucas1, Jesús Angulo, Pedro M Nieto
1Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, 41092 Sevilla, Spain.
Organic & Biomolecular Chemistry
|August 30, 2003
Abstract:
Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.