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Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer
Sharlene Gill1, Nevin Murray, Josep Dalmau
1Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
Background:
Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature.
Case Report:
The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer.
Conclusions:
This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.
