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Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis
Tetsushi Kaneko1, Masahiro Itoh, Yoichi Nakamura
1Department of Anatomy, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku Tokyo, Japan.
Cytokine
|August 30, 2003
Abstract:
We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.