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Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells
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Published on: May 24, 2018

[Shigella flexneri strains having a new type antigen 89-141].

S Matsushita1, S Yamada, Y Kudoh

  • 1Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|December 1, 1992
PubMed
Summary

Two atypical Shigella flexneri strains were identified in Tokyo. These pathogenic bacteria possess a novel antigen, distinct from known types, leading to the designation of strain 89-141 as a new type strain.

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Area of Science:

  • Microbiology
  • Immunology
  • Bacteriology

Context:

  • Shigella flexneri infections pose a global health challenge.
  • Emergence of atypical strains necessitates continuous surveillance and characterization.
  • Travel-associated infections highlight the importance of international disease monitoring.

Purpose:

  • To characterize two atypical Shigella strains isolated in Tokyo.
  • To investigate the serological and antigenic properties of these novel strains.
  • To determine the pathogenicity and genetic basis of these Shigella isolates.

Summary:

  • Two Shigella strains, 89-141 and 89-11, exhibited atypical serological reactions but typical biochemical profiles of Shigella flexneri.
  • Both strains demonstrated pathogenicity through Serény testing and cell invasion assays, possessing virulence plasmids.
  • Antigenic analysis revealed a novel type-specific antigen not previously identified in Shigella flexneri, leading to the designation of strain 89-141 as the type strain for this new antigen.

Impact:

  • Identifies a new antigenic type within Shigella flexneri, expanding the existing serological classification.
  • Contributes to a better understanding of Shigella diversity and evolution.
  • Informs diagnostic and epidemiological surveillance strategies for Shigella infections.