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Immune regulation by novel costimulatory molecules

Chen Dong1, Roza I Nurieva, Durbaka V R Prasad

  • 1Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195-7650, USA. chendong@u.washington.edu

Immunologic Research
|August 30, 2003
PubMed

CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.

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