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Related Experiment Videos

Disturbed vasomotion in chronic venous insufficiency.

Markus Stücker1, Jana Steinbrügge, Ulrike Memmel

  • 1Department of Dermatology and Allergology, Ruhr-University, Bochum, Germany. M.Stuecker@derma.de

Journal of Vascular Surgery
|August 30, 2003
PubMed
Summary

Patients with chronic venous insufficiency (CVI) show reduced vasomotion frequency when standing, leading to decreased oxygen supply and potentially microthrombi formation. This contrasts with healthy individuals whose vasomotion frequency increases upon standing.

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Area of Science:

  • Physiology
  • Vascular Biology
  • Dermatology

Background:

  • Vasomotion, the rhythmic contraction of small blood vessels, is crucial for capillary blood flow, cellular nutrition, and oxygen supply.
  • Impaired vasomotion can affect tissue oxygenation, particularly in conditions like chronic venous insufficiency (CVI).
  • Quantifying skin oxygen supply involves measuring hemoglobin oxygen saturation and oxyhemoglobin concentration.

Purpose of the Study:

  • To investigate the impact of chronic venous insufficiency (CVI) on vasomotion.
  • To compare vasomotion patterns in CVI patients and healthy controls under different postural conditions.

Main Methods:

  • Reflection spectrophotometry was used to measure intracutaneous changes in total hemoglobin, oxyhemoglobin, and hemoglobin oxygen saturation over 120 seconds.

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  • Subjects were measured in both supine and orthostatic (standing) positions.
  • Periodic variations were analyzed using modified digital Fourier transformation.

    • Main Results:

    • Both CVI patients and controls exhibited similar vasomotion frequencies in the supine position.
    • During orthostasis, vasomotion frequency significantly decreased in CVI patients (7.4 to 5.4 cpm) but significantly increased in controls (4.5 to 8.8 cpm).
    • Hemoglobin saturation and oxyhemoglobin concentration decreased more significantly in CVI patients compared to controls during orthostasis.

    Conclusions:

    • The inability to increase vasomotion frequency during standing in CVI patients results in prolonged distal vessel dilation.
    • This prolonged dilation may increase hematocrit, potentially promoting microthrombi formation in capillaries.
    • These vascular changes may contribute to perimalleolar tissue damage observed in CVI.