An expanded role for wild-type huntingtin in neuronal transcription

Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.

Human molecular genetics·2014

Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer.

PloS one·2014

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

Journal of Huntington's disease·2013

Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.

Neuro-degenerative diseases·2011

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2011

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Neuron·2010

Toward the clinical application of long-read sequencing in repeat-expansion disorders.

Nature genetics·2026

Distinguishing different psychiatric disorders using DDx-PRS.

Nature genetics·2026

Adaptive evolution of polyploid crops.

Nature genetics·2026

Rare variant effect estimation and polygenic risk prediction.

Nature genetics·2026

Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition.

Nature genetics·2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Nature genetics·2026

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington's disease.

Bioinformatics (Oxford, England)·2026

Association of HTR2A (rs6313) gene polymorphism with autism spectrum disorder in Jordanian children: a case-control study.

Drug metabolism and personalized therapy·2026

Single-cell Transcriptome-wide Mendelian Randomization and Colocalization Converge on Astrocytic TRIM66 as a Candidate Driver and Potential Therapeutic Target for Trigeminal Neuralgia.

Current medicinal chemistry·2026

A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development.

American journal of medical genetics. Part A·2026

Pathogenic Variants in PET Complex Encoding Genes TDRD12 and EXD1 Impair piRNA Biogenesis and Cause Male Infertility.

Human mutation·2026

Functional genomics in Xenopus identifies ARHGAP10 as a congenital heart disease and ciliopathy gene.

iScience·2026

Related Experiment Videos

An expanded role for wild-type huntingtin in neuronal transcription

Related Concept Videos

Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.

Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer.

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Toward the clinical application of long-read sequencing in repeat-expansion disorders.

Distinguishing different psychiatric disorders using DDx-PRS.

Adaptive evolution of polyploid crops.

Rare variant effect estimation and polygenic risk prediction.

Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition.

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington's disease.

Association of HTR2A (rs6313) gene polymorphism with autism spectrum disorder in Jordanian children: a case-control study.

Single-cell Transcriptome-wide Mendelian Randomization and Colocalization Converge on Astrocytic TRIM66 as a Candidate Driver and Potential Therapeutic Target for Trigeminal Neuralgia.

A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development.

Pathogenic Variants in PET Complex Encoding Genes TDRD12 and EXD1 Impair piRNA Biogenesis and Cause Male Infertility.

Functional genomics in Xenopus identifies ARHGAP10 as a congenital heart disease and ciliopathy gene.

Related Experiment Videos

An expanded role for wild-type huntingtin in neuronal transcription

Related Concept Videos

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