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Related Experiment Videos

Cdyl: a new transcriptional co-repressor.

Cécile Caron1, Christophe Pivot-Pajot, Leo A van Grunsven

  • 1Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation--INSERM U309, Equipe Chromatine et Expression des Gènes, Institut Albert Bonniot, Faculté de Médecine de Grenoble, Domaine de la Merci, 38706 La Tronche Cedex, France.

EMBO Reports
|August 30, 2003
PubMed
Summary

Chromodomain-Y-like (Cdyl) protein functions as a transcriptional co-repressor by binding histone deacetylases (HDACs). During spermiogenesis, Cdyl may bind coenzyme A (CoA) for chromatin remodeling when HDACs are degraded.

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Area of Science:

  • Reproductive biology
  • Molecular biology
  • Epigenetics

Background:

  • Cdyl (chromodomain-Y-like) is a protein predominantly expressed during mouse spermiogenesis.
  • Cdyl possesses a domain homologous to the coenzyme A (CoA) binding pocket of enoyl-CoA hydratase/isomerase.

Purpose of the Study:

  • To investigate the interaction of Cdyl with CoA and histone deacetylases (HDACs).
  • To elucidate the role of Cdyl in transcriptional regulation during spermiogenesis.

Main Methods:

  • Biochemical assays to assess CoA and HDAC binding.
  • Transcriptional repression assays.
  • Analysis of Cdyl and HDAC expression during mouse spermiogenesis.

Main Results:

Related Experiment Videos

  • Cdyl binds both CoA and HDACs.
  • HDAC1 binding to Cdyl inhibits CoA binding.
  • Cdyl acts as a transcriptional co-repressor.
  • HDAC1 and HDAC2 are degraded in elongating spermatids.

    • Conclusions:

    • Cdyl functions primarily as a transcriptional co-repressor through HDAC interaction.
    • The degradation of HDACs in elongating spermatids may allow Cdyl to bind CoA and participate in chromatin remodeling.