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Related Experiment Videos

Spinal cord claudication from amyloid deposition.

S Honig1, R Murali

  • 1Department of Rheumatology and Molecular Medicine, Hospital for Joint Diseases, New York, NY 10003.

The Journal of Rheumatology
|December 1, 1992
PubMed
Summary

A rare cause of spinal cord compression was identified in an 81-year-old woman. Thickened ligamentum flavum with amyloid deposition caused severe spinal stenosis, leading to claudication symptoms.

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Area of Science:

  • Neurology
  • Pathology
  • Spinal Surgery

Background:

  • Spinal cord claudication is a debilitating condition often caused by lumbar spinal stenosis.
  • Hypertrophied ligamentum flavum is a common contributor to spinal stenosis, but amyloid deposition is rare.

Observation:

  • An 81-year-old woman presented with worsening spinal cord claudication.
  • Imaging revealed severe lumbar spinal stenosis at L4-5 due to a hypertrophied ligamentum flavum.
  • Surgical findings confirmed severe dural tube compression by the thickened ligamentum flavum.

Findings:

  • Pathologic examination of the excised ligamentum flavum showed extensive amyloid protein deposition.
  • No underlying systemic or localized amyloidosis condition was identified.
  • This represents an unusual case of amyloid-associated spinal stenosis.

Implications:

  • This case highlights an uncommon etiology for spinal stenosis and associated neurological symptoms.
  • Further research may be needed to understand the pathogenesis of localized amyloid deposition in the ligamentum flavum.
  • Consideration of rare causes is important in managing refractory spinal cord claudication.

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