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[Determination of three components in compound chlorophenamine tablet by iterative target transformation factor
Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
|September 2, 2003
Summary
Iterative target transformation factor analysis accurately determined phenacetin, amidopyrine, and caffeine in compound chlorophenamine tablets. This analytical method demonstrated high precision and recovery rates for pharmaceutical quality control.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Context:
- Compound chlorophenamine tablets are a common pharmaceutical formulation.
- Accurate quantification of active pharmaceutical ingredients (APIs) is crucial for drug safety and efficacy.
Purpose:
- To develop and validate an analytical method for determining phenacetin, amidopyrine, and caffeine in compound chlorophenamine tablets.
- To assess the accuracy and precision of the proposed analytical technique.
Summary:
- Phenacetin, amidopyrine, and caffeine were quantified using iterative target transformation factor analysis (TTFA).
- The TTFA method achieved satisfactory results with high mean recoveries (100.4%, 99.2%, 99.4%) and low relative standard deviations (0.83%, 0.77%, 0.69%).
Impact:
- Provides a reliable analytical method for pharmaceutical quality control of multi-ingredient formulations.
- Ensures the accurate content of phenacetin, amidopyrine, and caffeine in chlorophenamine tablets, contributing to patient safety.