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[Interleukin 18 expression in colon cancer and adenoma]
Zhonghui Wen1, Qin Ouyang, Daiyun Chen
1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the expression of interleukin 18 in mucosa of colon cancer and adenoma.
Methods:
Expression of interleukin 18 was measured with immunohistochemical staining.
Results:
The expression rates of IL-18 in colon cancer, adenoma and relative normal mucosa were 78.8%, 100% and 100%, respectively (P > 0.05). In the case of colon cancer, the higher the cancer was differentiated, the higher the IL-18 expression level was observed (P < 0.05). In the case of colon adenoma, no significant relation was noted between the grade of dysplasia and the expression of IL-18 (P > 0.05).
Conclusion:
In colon adenoma, all mucosae express IL-18. But in colon cancer, IL-18 expression is decreased or absent, and the lower the cancer is differentiated, the lower will be the level of IL-18 expression in epithelium.