Related Experiment Videos
[A synthesis of dolichyl fluorophosphate]
O V Sizova1, S D Mal'tsev, V N Shibaev
1Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 119991 Russia.
Bioorganicheskaia Khimiia
|September 2, 2003
Abstract:
An improved method for the synthesis of dolichyl H-phosphonate was developed using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (salicyl chlorophosphite) as a reagent. Dolichyl phosphorofluoridate was for the first time synthesized from dolichyl H-phosphonate by its treatment with chlorotrimethylsilane, oxidation with iodine, and subsequent interaction with fluoride ion in pyridine.