[A rapid and effective solid-phase synthesis of DNA-sequence binding polyamides]
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Updated: Sep 20, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Abstract:
A rapid and effective variant of solid-phase synthesis of DNA-sequence-specific polyamides on the basis of 4-amino-1-methylpyrrole-2-carboxylic acid, 4-amino-1-methylimidazole-2-carboxylic acid, beta-alanine, and gamma-aminobutyric acid was suggested. It is based on the use of di- and trimeric oligocarboxamide building blocks, which help reduce the time of synthesis, increase its yield and purity of products, and efficiently use manual synthesis for the synthesis of long oligocarboxamides. The yields of hairpin ligands with up to 10 units are 35-50% and the synthesis takes no more than 6 h.
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