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Related Experiment Videos

Xenobiotic bioconversion in human epidermis models.

Audra L Stinchcomb1

  • 1Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Lexington, Kentucky 40536-0082, USA. astin2@email.uky.edu

Pharmaceutical Research
|September 2, 2003
PubMed
Summary

New skin bioequivalent models offer alternatives to animal testing for measuring xenobiotic biotransformation. These models are increasingly used in dermatopharmacology for drug metabolism and toxicology studies.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Dermatology

Background:

  • Traditional methods for assessing skin metabolism and toxicity rely on animal testing and excised human skin.
  • These methods face ethical and practical limitations, driving the need for alternatives.
  • Human skin epidermal bioequivalents are emerging as viable replacements.

Purpose of the Study:

  • To review the utility of human skin bioequivalent models for xenobiotic biotransformation studies.
  • To highlight their application in pharmacological and toxicological assessments relevant to dermatopharmaceutical science.

Main Methods:

  • Review of published literature on skin bioequivalent models.
  • Analysis of data on the use of cell cultures, tissue sheets, and differentiated epidermal/epidermal-dermal systems.

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  • Evaluation of their application in metabolism and toxicology studies.

    • Main Results:

    • Human skin bioequivalent models, including cell cultures and tissue-engineered systems, are increasingly utilized.
    • These models demonstrate utility in studying drug and chemical metabolism within the skin.
    • Published data support their application in various toxicology assessments.

    Conclusions:

    • Human skin bioequivalent models provide valuable alternatives to traditional methods for studying percutaneous xenobiotic biotransformation.
    • These models are suitable for a range of pharmacological and toxicological investigations in dermatopharmacology.
    • Further research and validation will enhance their role in drug development and safety assessment.