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Relation between stage of left ventricular diastolic dysfunction and QT dispersion
Huseyin Gunduz1, Ramazan Akdemir, Emrah Binak
1Abant Izzet Baysal University, Izzet Baysal Medical Faculty, Department of Cardiology, Bolu, Turkey. drhuseyingunduz@yahoo.com
Acta Cardiologica
|September 2, 2003
Summary
This study found that increased stages of left ventricular diastolic dysfunction correlate with higher QT dispersion, indicating greater arrhythmia risk. Ischemic heart disease showed significantly higher QT dispersion than left ventricular hypertrophy.
Area of Science:
- Cardiology
- Electrophysiology
- Echocardiography
Background:
- Diastolic dysfunction affects 30-40% of heart failure patients with normal systolic function.
- Evaluating diastolic function is crucial for early diagnosis, treatment, and prognosis.
- QT dispersion reflects ventricular repolarization heterogeneity and predicts arrhythmia risk.
Purpose of the Study:
- To investigate the correlation between left ventricular diastolic function stages and QT dispersion.
- To compare QT dispersion in patients with diastolic dysfunction due to ischemic heart disease versus left ventricular hypertrophy.
Main Methods:
- Echocardiography assessed left ventricular diastolic function in 80 patients, categorized into four stages (0-3).
- QT dispersion (QT D) and corrected QT dispersion (QTc D) were measured using Bazzett's formula from ECGs.
- Patients were grouped by diastolic dysfunction stage and etiology (ischemic heart disease vs. left ventricular hypertrophy).
Main Results:
- A significant direct relationship was observed between increasing left ventricular diastolic dysfunction stage and elevated QT D and QTc D (p<0.01).
- QT D and QTc D were significantly higher in patients with ischemic heart disease compared to those with left ventricular hypertrophy (p<0.01).
Conclusions:
- QT dispersion increases with the severity of left ventricular diastolic dysfunction.
- Ischemic heart disease is associated with greater QT dispersion compared to left ventricular hypertrophy in diastolic dysfunction.