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Related Experiment Videos

Assisted hatching--a meta-analysis of randomized controlled trials.

Hassan N Sallam1, Sameh S Sadek, Abdel Fattah Agameya

  • 1Department of Obstetrics and Gynecology, the University of Alexandria, Alexandria, Egypt. hnsallam@link.net

Journal of Assisted Reproduction and Genetics
|September 2, 2003
PubMed
Summary

Assisted hatching significantly improves pregnancy, implantation, and ongoing pregnancy rates for patients with poor prognosis undergoing IVF or ICSI. This benefit is particularly pronounced in those experiencing repeated IVF failures.

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Assisted hatching is a laboratory procedure used in assisted reproductive technology.
  • Its efficacy in improving pregnancy outcomes, especially for specific patient groups, requires robust evaluation.

Purpose of the Study:

  • To perform a meta-analysis of randomized controlled trials (RCTs) evaluating the effectiveness of assisted hatching.
  • To assess the impact of assisted hatching on pregnancy, implantation, and ongoing pregnancy rates.

Main Methods:

  • A systematic literature search identified 165 studies, with 13 meeting the inclusion criteria.
  • Meta-analysis was conducted using RevMan software employing the Peto-modified Mantel-Haenszel method.

Main Results:

Related Experiment Videos

  • Assisted hatching demonstrated significant increases in pregnancy (OR 2.51), implantation (OR 2.38), and ongoing pregnancy rates (OR 2.65) for poor prognosis patients undergoing IVF/ICSI.
  • For patients with recurrent IVF failures, assisted hatching showed even greater benefits: pregnancy (OR 2.84), implantation (OR 2.53), and ongoing pregnancy (OR 3.51).

    • Conclusions:

    • Assisted hatching is a valuable adjunct for improving IVF/ICSI success rates in patients with poor prognosis.
    • The procedure is particularly beneficial for individuals with a history of repeated implantation failures.