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Corneal lattice dystrophy, a concealed ophthalmic problem in Thailand
Pinnita Prabhasawat1, Somanus Thoongsuwan, Nattaporn Tesavibul
1Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|September 2, 2003
Summary
Corneal lattice dystrophy in one family showed varied symptoms and significant visual impairment, impacting daily life. Early diagnosis and patient education are crucial for managing this autosomal dominant condition.
Area of Science:
- Ophthalmology
- Genetics
- Clinical Medicine
Background:
- Corneal lattice dystrophy is a hereditary eye condition.
- Understanding its clinical variability within families is important for diagnosis and management.
Purpose of the Study:
- To investigate the clinical manifestations, visual impairment factors, and quality of life impacts in a single family affected by corneal lattice dystrophy.
- To analyze the relationship between disease characteristics and visual outcomes.
Main Methods:
- Interview and examination of 88 family members from one family with corneal lattice dystrophy.
- Assessment of corneal haze and surface irregularity using grading scales.
- Evaluation of visual acuity (VA) and correlation with clinical findings and disease duration.
Main Results:
- 48.9% of family members were affected, with an autosomal dominant inheritance pattern.
- Significant visual impairment (VA ≤ 20/200) was observed in 45% of patients.
- Corneal haziness, irregularity, erosion, and disease duration were significantly associated with visual impairment (p < 0.05).
- Affected individuals experienced substantial disruption in reading, working, and daily activities.
Conclusions:
- Corneal lattice dystrophy exhibits variable clinical presentations within the same family, influenced by severity and duration.
- Misdiagnosis is possible due to varied manifestations.
- Inadequate patient knowledge contributes to disease prevalence and impaired quality of life, highlighting the need for better awareness and management strategies.