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Updated: Sep 20, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus
Z Sumník1, P Drevínek, M Snajderová
12nd Department of Pediatrics, 2nd Medical School, Charles University, Prague, Czech Republic. Zdenek.Sumnik@Lfmotol.cuni.cz
Objective:
Type 1 diabetes mellitus (DM1) is frequently accompanied by thyroid autoimmunity (TAI). The aims of the present study were to estimate the prevalence of TAI and to determine the contribution of HLA-DQA1 and -DQB1 polymorphisms to TAI susceptibility among children with DM1. PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP.
Results:
Repeated positivity of anti-TPO and/or anti-Tg was found in 45/285 children with DM1 (15.8%). The prevalence was significantly higher in girls than in boys (26.7% vs 6.7%; p<10(-5)). The HLA-DQB1*0302 allele conferred susceptibility to TAI in children with DM1 (OR 2.7, 95% CI 1.1-6.4), while the DQB1*05 alleles acted protectively (OR 0.2, CI 95% 0.08-0.7).
Conclusions:
HLA-DQ polymorphisms significantly modify the risk of TAI in children with DM1.
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