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Hypophosphatemic rickets and osteomalacia in polyostotic fibrous dysplasia
Arijit Chattopadhyay1, Anil Bhansali, Sambit K Mohanty
1Department of Endocrinology, PGIMER, Chandigarh, India.
Abstract:
A 17 year-old girl with polyostotic fibrous dysplasia and hypophosphatemia had inappropriately low tubular reabsorption of phosphate. She had radiological evidence of rickets and osteomalacia. The patient showed clinical improvement after treatment with phosphate supplementation, active vitamin D (calcitriol) and alendronate. It is postulated that either a phosphaturic substance elaborated from the dysplastic bone or target-organ (kidney) unresponsiveness may interfere with phosphate reabsorption in the renal tubule.
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