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Optic nerve alterations in apolipoprotein E deficient mice.

E Lopez-Sanchez1, E Frances-Muñoz, A Diez-Juan

  • 1Hospital La Fé, Valencia, Spain.

European Journal of Ophthalmology
|September 2, 2003
PubMed
Summary
This summary is machine-generated.

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Apolipoprotein E (ApoE) knockout mice exhibit altered optic nerve morphology and myelination. These findings highlight ApoE

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Genetics

Background:

  • Apolipoprotein E (ApoE) plays a crucial role in lipid metabolism and neuronal repair.
  • Dysregulation of ApoE is implicated in various neurological disorders.

Purpose of the Study:

  • To investigate the impact of ApoE gene knockout on the morphologic characteristics of the optic nerve (ON).
  • To assess ON changes in ApoE knockout mice, with and without a cholesterol-supplemented diet.

Main Methods:

  • Morphologic and morphometric analyses of optic nerves from wild-type and ApoE knockout mice.
  • Light and transmission electron microscopy were employed.
  • Three groups were studied: control, ApoE knockout, and ApoE knockout on a cholesterol-rich diet.

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Main Results:

  • ApoE knockout mice showed a significantly increased ON cross-sectional area compared to controls.
  • Alterations in the myelination index and increased intra-axonal degeneration were observed in ApoE knockout groups.
  • No significant differences in ON morphology were found between ApoE knockout mice fed a standard or cholesterol-supplemented diet.

Conclusions:

  • ApoE deficiency leads to notable changes in optic nerve morphology and myelination.
  • These findings suggest a role for ApoE in maintaining optic nerve integrity.