Antimicrobial peptides containing arginine
Related Experiment Video
Updated: Sep 20, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
M G Ryadnov1, O V Degtyareva, I A Kashparov
1Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.
Abstract:
Tetradecapeptides (RLARLAR)2, D-(RLARLAR)2, (RLARLAA)2, and (RLGRLGR)2 were synthesized by a solid phase method using Fmoc-amino acids. The antibacterial activity of the synthesized peptides was studied against Escherichia coli cells. The minimum inhibitory concentration (MIC) was, correspondingly, 3, 1, 3, and 12 micro M, which is comparable with MIC of such natural antimicrobial peptides as temporin, magainin, and dermaseptin. It was found that all of the synthesized peptides have no effect on human erythrocytes and rat thymocytes. The peptides form alpha-helices in 30% trifluoroethanol and in 2.5 mM SDS, which have amphipathic structure.
More Related Videos
Related Concept Videos
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Amino acids
Inhibitors of Bacterial Protein Synthesis
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Clinical Significance of Antibiotic Resistance
Gene Regulation in Microbial Communities: Quorum Sensing

