Making (a) sense of non-visual ocular photoreception
Related Experiment Video
Updated: Sep 12, 2026

Determination of Photoreceptor Cell Spectral Sensitivity in an Insect Model from In Vivo Intracellular Recordings
Published on: February 26, 2016
1Department of Ophthalmology and Visual Sciences, Washington University Medical School, Campus Box 8096, 660 S. Euclid Avenue, St Louis, MO 63110, USA. vangelder@vision.wustl.edu
Abstract:
A subset of intrinsically photosensitive retinal ganglion cells transduce information about ambient lighting conditions to areas of the brain involved in tasks including entrainment of the circadian clock, pupillary light reflexes and melatonin synthesis. The phototransduction system(s) utilized by these cells are unknown. Melanopsin and cryptochromes have been proposed as candidate photopigments for this system. Recent analyses of retinal degenerate mice lacking melanopsin or cryptochromes indicates that outer and inner photoreceptors can both contribute to non-visual photoresponses, and that both melanopsin and cryptochromes play important roles in this process.
Related Concept Videos
The Retina
Vision
G-Protein Gated Ion Channels
Sensory organs,...
Anatomy of the Eyeball
Photoreceptors and Visual Pathways
Visual System
Once through the pupil, the light passes through the lens, a...

