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Magnetoencephalographic studies of two cases of diffuse subcortical laminar heterotopia or so-called double cortex
Pierre Toulouse1, Cyril Agulhon, Delphine Taussig
1Laboratoire de Physiologie-Explorations Fonctionnelles, Université de Rennes I, CHU Rennes, Rue Henri Le Guilloux, 35033 Rennes Cedex, France. pierre.toulouse@chu-rennes.fr
Abstract:
Two cases (a young male and a girl, suffering intractable epilepsy) of diffuse subcortical laminar heterotopia, or so-called double cortex (DC) have been investigated using magnetoencephalography (MEG). MEG confirmed involvement of both cortices (hetero- and normocortex) in the genesis of interictal spikes, and, according to the heterogeneity of DC syndrome, some differences were observed: spike initiation in the normocortex and latter involvement of the heterotopic cortex in the man, and rather a cancellation in both cortices in the girl. In addition, participation of heterotopic cortex in physiological activities could be demonstrated in the man.