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The versatile beta-barrel membrane protein.

William C Wimley1

  • 1Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA. wwimley@tulane.edu

Current Opinion in Structural Biology
|September 2, 2003
PubMed
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Beta-barrel proteins are crucial components in bacterial outer membranes, mitochondria, and chloroplasts. Research highlights the vast diversity in their structures and functions, expanding beyond the few known 3D structures.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Beta-barrel proteins are integral membrane proteins located in the outer membranes of various cellular compartments.
  • These proteins constitute a significant portion (2-3%) of genes in Gram-negative bacteria.
  • Despite a limited number of determined 3D structures, genomic data suggests a vast repertoire of beta-barrels.

Purpose of the Study:

  • To highlight the structural and functional diversity of beta-barrel proteins.
  • To underscore the discrepancy between known structures and the abundance of beta-barrel genes in genomic databases.
  • To emphasize the ongoing discovery of novel beta-barrel protein functions.

Main Methods:

  • Bioinformatic analysis of genomic databases to identify beta-barrel encoding genes.

Related Experiment Videos

  • Comparative analysis of known three-dimensional beta-barrel structures.
  • Literature review of recent research on beta-barrel protein function and structure.

    • Main Results:

    • Genomic databases contain thousands of beta-barrel proteins across dozens of families.
    • Fewer than 20 distinct three-dimensional beta-barrel structures have been experimentally determined.
    • Emerging research reveals a wide array of functions associated with these proteins.

    Conclusions:

    • The structural and functional diversity of beta-barrel proteins is significantly underestimated.
    • Further research is needed to elucidate the structures and functions of the numerous uncharacterized beta-barrels.
    • Beta-barrel proteins represent a versatile class of molecules with broad biological significance.