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Psoriasis during therapy with olanzapine.
Alessandra Latini1, Massimo Carducci
1Dipartimento di Dermatologia Infiammatoria, Polo Dermatologico S. Gallicano (IRCCS) Via Elio Chianesi, 53, 00144 Rome, Italy.
European Journal of Dermatology : EJD
|September 2, 2003
Summary
Olanzapine, used for psychotic disorders, may trigger or worsen psoriasis. This study reports two cases, highlighting the need for caution in patients with psoriasis or a family history.
Area of Science:
- Dermatology
- Psychiatry
- Pharmacology
Background:
- Psoriasis exacerbation is linked to various medications, but the role of newer antipsychotics is unclear.
- Olanzapine is a widely used atypical antipsychotic for treating psychotic disorders.
Observation:
- Two cases of psoriasis associated with olanzapine treatment are presented.
- Case 1: Worsening and relapse of pre-existing psoriasis after olanzapine initiation.
- Case 2: New-onset psoriasis during olanzapine treatment in a patient with a family history.
Findings:
- Olanzapine treatment was temporally associated with both the exacerbation of existing psoriasis and the onset of new-onset psoriasis.
- The exact mechanism linking olanzapine to psoriasis development or worsening remains undetermined.
Implications:
- Healthcare providers should exercise caution when prescribing olanzapine to patients with psoriasis or a family history.
- Close dermatological monitoring is recommended for patients on olanzapine, especially those with a predisposition to psoriasis.