Mode of action of fibrates

Fibrates are a class of hypolipidaemic drugs that effectively reduce plasma triglyceride and cholesterol levels, but also raise HDL cholesterol. In recent years the attention of pharmacologists and clinicians to fibrates has been renewed also in the light of a multifaceted action on plasma lipids as well as on factors modulating the thrombotic homeostasis in blood. The mechanisms of actions underlying these effects are discussed in this short review.