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Hepatosplenic lymphoma in a dog
M M Fry1, W Vernau, P A Pesavento
1Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Veterinary Pathology
|September 2, 2003
Summary
This study reports the first canine case of hepatosplenic lymphoma, a rare cancer affecting the liver and spleen with gammadelta T cells. The disease course in this dog mirrored human cases, aiding diagnosis.
Area of Science:
- Veterinary Oncology
- Immunology
Background:
- Hepatosplenic lymphoma is a rare and aggressive T-cell lymphoma primarily affecting the liver, spleen, and bone marrow.
- This specific subtype is characterized by the absence of peripheral lymphadenopathy and a rapid clinical progression.
Observation:
- A canine patient presented with clinical signs, hematologic, and biochemical abnormalities consistent with aggressive systemic disease.
- Physical examination and diagnostic procedures revealed infiltration of the liver and spleen, with no peripheral lymph node enlargement.
Findings:
- Immunophenotyping of aspirates supported a diagnosis of T-cell lymphoma.
- Postmortem histopathology and immunohistochemistry confirmed hepatosplenic lymphoma, identifying neoplastic lymphocytes as gammadelta T cells.
Implications:
- This case represents the first documented instance of hepatosplenic lymphoma in a dog.
- Understanding this condition in dogs may offer insights into comparative oncology and human T-cell lymphomas.