Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Residual lymphocytes after specific depletion. Functional study].

D Valteau-Couanet, M Cavazzana-Calvo, A Fischer

    Presse Medicale (Paris, France : 1983)
    |December 2, 1992
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    CD2-induced apoptosis in activated human peripheral T cells: a Fas-independent pathway that requires early protein tyrosine phosphorylation.

    Journal of immunology (Baltimore, Md. : 1950)·1996
    Same author

    Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts.

    European journal of immunology·1996
    Same author

    gamma-c gene transfer into SCID X1 patients' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function.

    Blood·1996
    Same author

    Clinical, hematologic, and biochemical features of a syndrome in Bernese mountain dogs characterized by hepatocerebellar degeneration.

    Journal of the American Veterinary Medical Association·1996
    Same author

    A phase II trial of partially incompatible bone marrow transplantation for high-risk acute lymphoblastic leukaemia in children: prevention of graft rejection with anti-LFA-1 and anti-CD2 antibodies. Société Française de Greffe de Moelle Osseuse.

    British journal of haematology·1996
    Same author

    Radiommunological measurement of leptin in plasma of obese and diabetic human subjects.

    Endocrinology·1996
    Same journal

    Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Ethical, legal, and regulatory challenges in AI-based healthcare tools.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Decision-making for clinicians.

    Presse medicale (Paris, France : 1983)·2026
    See all related articles

    Selective T cell depletion using a targeted toxin effectively removes alloreactive T cells without compromising immune responses to common infections like cytomegalovirus and candida post-bone marrow transplant.

    Area of Science:

    • Immunology
    • Cell Biology
    • Transplantation Science

    Context:

    • Alloreactive T cells drive graft-versus-host disease and graft rejection in MHC-incompatible bone marrow transplantation.
    • Selective depletion of these cells is crucial for successful transplantation outcomes.
    • Previous work established a targeted toxin approach for T cell depletion.

    Purpose:

    • To evaluate the impact of a targeted T cell depletion method on immune reactivity to microbial antigens post-bone marrow transplant (BMT).
    • To determine if selective alloreactive T cell depletion affects T cell responses to cytomegalovirus and candida antigens.

    Summary:

    • A ricin A-chain conjugated to an anti-IL2 receptor p55 subunit selectively killed activated alloreactive T cells.
    • This method demonstrated minimal non-specific killing of T cells from a third party.

    Related Experiment Videos

  • Post-transplant, T cell proliferation assays and limiting dilution analysis confirmed preserved reactivity to cytomegalovirus and candida antigens.

    • Impact:

    • The T cell depletion strategy shows potential for preventing graft-versus-host disease and graft rejection in BMT.
    • This method preserves essential T cell functions, allowing the host to mount effective immune responses against common infections following transplantation.
    • This research supports the clinical applicability of targeted T cell depletion in bone marrow transplantation.